Reacción #550468

Ecuación de reacción

1-[4-(4-chlorophenyl)-2-(4-acetylamino-2,6-dichlorophenoxy)-n-butyl]imidazole

potassium carbonate

→

1-[4-(4-chlorophenyl)-2-(4-amino-2,6-dichlorophenoxy)-n-butyl]imidazole bis(hydrochloride)

Disolventes

hydrochloric acid

Condiciones de reacción

Tratamiento posterior

1. 1
   Extracciónextracted with ethyl acetate (3×75 ml)
2. 2
   Secadothe combined extracts dried (MgSO4)
3. 3
   Otroevaporated
4. 4
   workup.DISSOLUTIONThe resulting oil (1.3 g) was dissolved in ether
5. 5
   workup.ADDITIONtreated with ethereal hydrogen chloride until precipitation
6. 6
   FiltraciónThe product was filtered off
7. 7
   Otrodried immediately in vacuo

Procedimiento

A solution of 1-[4-(4-chlorophenyl)-2-(4-acetylamino-2,6-dichlorophenoxy)-n-butyl]imidazole (1.58 g) (prepared as in Example 1) in 15 ml of concentrated hydrochloric acid was heated at 90° C. for 1 day. The resulting solution was poured into 200 ml of aqueous potassium carbonate solution, extracted with ethyl acetate (3×75 ml) and the combined extracts dried (MgSO4) and evaporated. The resulting oil (1.3 g) was dissolved in ether and treated with ethereal hydrogen chloride until precipitation was complete. The product was filtered off and dried immediately in vacuo to give 1.4 g of 1-[4-(4-chlorophenyl)-2-(4-amino-2,6-dichlorophenoxy)-n-butyl]imidazole bis(hydrochloride), m.p. 119°-123° C.

Fuente