Reacción #55033

Ecuación de reacción

bromocyclopentane

N-(4-chlorophenyl)-N-(4-piperidinyl)benzeneacetamide

sodium carbonate

potassium iodide

bromocyclopentane

→

N-(4-chlorophenyl)-N-(1-cyclopentyl-4-piperidinyl)benzeneacetamide

Condiciones de reacción

Tratamiento posterior

1. 1
   Temperaturawarm
2. 2
   workup.STIRRINGthe whole is stirred
3. 3
   Temperaturarefluxed for 21h.30
4. 4
   workup.STIRRINGstirring
5. 5
   Temperaturaat reflux temperature
6. 6
   TemperaturaThe reaction mixture is cooled
7. 7
   Filtraciónfiltered
8. 8
   Otrothe filtrate is evaporated
9. 9
   Otroon triturating in 1,1'-oxybisethane
10. 10
    FiltraciónThe solid product is filtered off
11. 11
    Otrocrystallized from 1,1'-oxybisethane

Procedimiento

to a stirred and warm (40° C.) mixture of 5 parts of N-(4-chlorophenyl)-N-(4-piperidinyl)benzeneacetamide, 5 parts of sodium carbonate, a few crystals of potassium iodide and 200 parts of nbutanol is added 3.75 parts of bromocyclopentane and the whole is stirred and refluxed for 21h.30. Then a second portion of 5 parts of bromocyclopentane is added and stirring at reflux temperature is continued for another 30 hours. The reaction mixture is cooled, filtered and the filtrate is evaporated. The oily residue solidifies on triturating in 1,1'-oxybisethane. The solid product is filtered off and crystallized from 1,1'-oxybisethane, yielding 1.1 parts of N-(4-chlorophenyl)-N-(1-cyclopentyl-4-piperidinyl)benzeneacetamide; mp. 139.5° C.

Fuente