Reacción #55004

Ecuación de reacción

Lead cyanamide

1,3-bis-[N'-(2-(5-methyl-4-imidazolylmethylthio)ethyl)thioureido] propane

acetonitrile

Dimethylformamide

→

title compound

1,3-bis-[N'-Cyano-N"-(2-(5-methyl-4-imidazolylmethylthio)ethyl)guanidino]propane

Condiciones de reacción

Tratamiento posterior

1. 1
   Temperaturaunder reflux for 24 hours
2. 2
   FiltraciónThe mixture was filtered
3. 3
   Concentraciónconcentrated
4. 4
   Otropurified by chromatography

Procedimiento

Lead cyanamide (3.0 g) was added to 1,3-bis-[N'-(2-(5-methyl-4-imidazolylmethylthio)ethyl)thioureido] propane (2.5 g) in acetonitrile. Dimethylformamide was added and the mixture was stirred and boiled under reflux for 24 hours. The mixture was filtered, concentrated and purified by chromatography to give the title compound.

Fuente