Reacción #549413

Ecuación de reacción

2-(2-chloro-5-thiadiazolyl)-1-methyl-5-nitroimidazole

2-[2-(Hydroxyethylamino)-5-thiadiazolyl]-1-methyl- 5-nitroimidazole

2,2-diethoxyethylamine

dioxane

→

compound

2-[2-(2,2-diethoxyethylamino)-5-thiadiazolyl]-1-methyl-5-nitroimidazole

Disolventes

water

Condiciones de reacción

Tratamiento posterior

1. 1
   Temperaturaheated on the steam bath for 12 hours
2. 2
   workup.ADDITIONIt is then diluted with 500 ml
3. 3
   Otrothe precipitated yellow solid collected
4. 4
   Otrodried
5. 5
   OtroRecrystallization from 505 aqueous ethanol

Procedimiento

A mixture composed 9.8 g. of 2-(2-chloro-5-thiadiazolyl)-1-methyl-5-nitroimidazole, (Example 16), 11.0 g. of 2,2-diethoxyethylamine, and 250 ml. of dioxane is stirred and heated on the steam bath for 12 hours. It is then diluted with 500 ml. of cold water, cooled, and the precipitated yellow solid collected and dried. Recrystallization from 505 aqueous ethanol gives the pure compound melting at 154°-155° C.

Fuente