Reacción #54891

Ecuación de reacción

4-(4-acetyl-8-hydroxytridecyl)benzoic acid

acetic anhydride

→

crude product

4-(4-Acetyl-8-acetoxytridecyl)benzoic Acid

Disolventes

ethyl ether

Condiciones de reacción

Tratamiento posterior

1. 1
   TemperaturaThe mixture is then cooled
2. 2
   workup.DISSOLUTIONdissolved in 80 ml
3. 3
   ExtracciónThe solution is extracted with an ice-cold solution of 8 g
4. 4
   OtroThe basic solution is separated
5. 5
   Lavadowashed with water
6. 6
   Secadodried over sodium sulfate
7. 7
   OtroThe ether is evaporated

Procedimiento

A mixture of 4-(4-acetyl-8-hydroxytridecyl)benzoic acid (9.0 g., 0.025 mole) and acetic anhydride (6.1 g., 0.06 mole) is heated at 60° C. for 18 hours. The mixture is then cooled and dissolved in 80 ml. ethyl ether. The solution is extracted with an ice-cold solution of 8 g. sodium hydroxide in 150 ml. water. The basic solution is separated and acidified with concentrated hydrochloric acid. The oily acid which separates is taken up in ether, washed with water, and dried over sodium sulfate. The ether is evaporated to leave the oily crude product.

Fuente