Reacción #54882

Ecuación de reacción

4-[4-Acetyl-7-(1-hydroxycyclohexyl)-6-heptyn-1-yl]benzoic acid

hydrogen

→

title compound

4-[4-Acetyl-7-(1-hydroxycyclohexyl)heptyl]benzoic Acid

Disolventes

ethyl acetate

Condiciones de reacción

Tratamiento posterior

1. 1
   Otroat 1 atmosphere pressure and room temperature
2. 2
   FiltraciónThe catalyst is filtered off
3. 3
   Otrothe solvent is evaporated
4. 4
   Otrothe residue (5 g.) is chromatographed on 75 g

Procedimiento

4-[4-Acetyl-7-(1-hydroxycyclohexyl)-6-heptyn-1-yl]benzoic acid (5.1 g., 0.014 mole) in ethyl acetate (55 ml.) is hydrogenated over 2.0 g. of a 5% Pt on charcoal catalyst at 1 atmosphere pressure and room temperature. The theoretical amount of hydrogen (0.028 mole) is absorbed in 25 minutes. The catalyst is filtered off, the solvent is evaporated and the residue (5 g.) is chromatographed on 75 g. of silica gel with 2% methanol in chloroform as eluant. The title compound is obtained as a colorless viscous oil.

Fuente