Reacción #547717

Ecuación de reacción

6-[3-(4-methylphenyl)-4-aminophenyl]oxyhexanoic acid methyl ester

1,2-dichloroethane

phenylisocyanide dichloride

water

→

6-[[1-(4-Methylphenyl)-2-phenylamino-1H-benzimidazol-6-yl]oxy]hexanoic acid methyl ester

Condiciones de reacción

Tratamiento posterior

1. 1
   Temperaturathe mixture was heated for 8 hours to 65° C
2. 2
   TemperaturaAfter cooling
3. 3
   Extracciónextracted three times with ethyl acetate
4. 4
   Lavadothe combined organic phases were washed with saturated sodium chloride solution
5. 5
   Otrodried on sodium sulfate
6. 6
   Concentraciónconcentrated by evaporation in a vacuum
7. 7
   OtroThe residue was crystallized from a mixture that
8. 8
   Otro147 mg was obtained

Procedimiento

250 mg of 6-[3-(4-methylphenyl)-4-aminophenyl]oxyhexanoic acid methyl ester was dissolved in 1 ml of 1,2-dichloroethane, the solution was mixed with 0.1 ml of phenylisocyanide dichloride, and the mixture was heated for 8 hours to 65° C. After cooling, it was mixed with water, extracted three times with ethyl acetate, the combined organic phases were washed with saturated sodium chloride solution, dried on sodium sulfate and concentrated by evaporation in a vacuum. The residue was crystallized from a mixture that consists of ethyl acetate and diethyl ether. 147 mg was obtained.

Fuente