Reacción #547305

Ecuación de reacción

Tetra-butylammonium fluoride

4-tri-isopropoxymethyl-2-(4′-methoxyphenyl)acetanilide

→

yellow oil

Rendimiento 149.2%

4-Hydroxymethyl-2-(4′-methoxyphenyl)acetanilide

Rendimiento 149.2%

Disolventes

ethyl acetate

THF

THF

Condiciones de reacción

Tratamiento posterior

1. 1
   Lavadowashed with saturated ammonium chloride
2. 2
   Secadowater and finally dried over sodium sulphate
3. 3
   OtroThe solvent was evaporated

Procedimiento

Tetra-butylammonium fluoride (4.48 mL of a 1M solution in THF) was added to a solution of 4-tri-isopropoxymethyl-2-(4′-methoxyphenyl)acetanilide (1.87 g, 4.07 mmol) in THF (12 mL) and stirred for 2 hours. The reaction was diluted with ethyl acetate and washed with saturated ammonium chloride then water and finally dried over sodium sulphate. The solvent was evaporated to afford 1.66 g of a yellow oil.

Fuente