Reacción #54657

Ecuación de reacción

4-amino-3-nitrobenzophenone

hydrogen

→

3,4-diaminobenzophenone

Rendimiento 100.0%

Disolventes

tetrahydrofuran

Condiciones de reacción

Tratamiento posterior

1. 1
   Otrowas hydrogenated at room temperature in 945 ml
2. 2
   FiltraciónThe catalyst was filtered
3. 3
   Otrothe filtrate was evaporated in vacuo to a solid residue
4. 4
   OtroThe residue was chromatographed over silica gel
5. 5
   Otroto yield 43.6 g

Procedimiento

Fifty grams of 4-amino-3-nitrobenzophenone was hydrogenated at room temperature in 945 ml. of tetrahydrofuran with 15 g. of Raney nickel at 40 psi. After 4 hours three equivalents of hydrogen were absorbed. The catalyst was filtered and the filtrate was evaporated in vacuo to a solid residue. The residue was chromatographed over silica gel using ethyl acetate as eluant. Fractions 5-9 were combined to yield 43.6 g. (100 percent yield) of 3,4-diaminobenzophenone.

Fuente