Reacción #54642

Ecuación de reacción

trichlorobenzene

8-chloro-5-amino-quinaldine

phthalic anhydride

→

8-chloro-5-phthalimidoquinaldine

Rendimiento 83.3%

Condiciones de reacción

Tratamiento posterior

1. 1
   Otrothe mixture was reacted
2. 2
   Temperaturaunder reflux for 2 hours at the boiling point
3. 3
   TemperaturaAfter cooling
4. 4
   Otrothe precipitated crystals were separated by filtration
5. 5
   Otrodried

Procedimiento

95 g of trichlorobenzene was added to 23.3 g (0.12 mole) of 8-chloro-5-amino-quinaldine and 18.0 g (0.12 mole) of phthalic anhydride, and the mixture was reacted under reflux for 2 hours at the boiling point. After cooling, the precipitated crystals were separated by filtration, and dried to afford 32 g (0.10 mole) of 8-chloro-5-phthalimidoquinaldine.

Fuente