Reacción #54591

Ecuación de reacción

water

Chloroform

potassium phthalimide

ethyl-2-bromopentanoate

→

ethyl α-phthalimidopentanoate

Disolventes

DMF

dimethylformamide

Condiciones de reacción

Tratamiento posterior

1. 1
   OtroThe phases are separated
2. 2
   Extracciónthe aqueous phase is extracted with chloroform
3. 3
   Extracciónextracted with 0.1 N sodium hydroxide and with water
4. 4
   SecadoAfter drying over sodium sulfate
5. 5
   Otrothe chloroform is removed

Procedimiento

To a solution of potassium phthalimide (0.1 mole) in about 50 ml of dimethylformamide (DMF) is added 1 equivalent of ethyl-2-bromopentanoate. The temperature is maintained at about 60° C. for 10 minutes. Chloroform is added to the cooled DMF solution and the mixture is poured into water. The phases are separated and the aqueous phase is extracted with chloroform. The chloroform extracts are combined, extracted with 0.1 N sodium hydroxide and with water. After drying over sodium sulfate, the chloroform is removed to give ethyl α-phthalimidopentanoate.

Fuente