Reacción #54507

Ecuación de reacción

ethyl 4-(2-methylphenyl)-3-oxobutanoate

sodium methoxide

1-bromododecane

potassium iodide

→

ethyl 2-[(2-methylphenyl)acetyl]tetradecanoate

Disolventes

ethanol

Condiciones de reacción

Tratamiento posterior

1. 1
   OtroThe mixture was evaporated to a small volume
2. 2
   workup.ADDITIONdiluted with 100 parts water
3. 3
   Extracciónextracted with ether
4. 4
   ExtracciónThe ether extract
5. 5
   Lavadowas washed with saturated sodium bicarbonate, saturated sodium chloride solution
6. 6
   Secadodried over magnesium sulfate
7. 7
   OtroEvaporation of the ether

Procedimiento

Three parts of ethyl 4-(2-methylphenyl)-3-oxobutanoate, 1 part of sodium methoxide, 4.6 parts of 1-bromododecane, 0.5 parts of potassium iodide and 50 parts of absolute ethanol were refluxed together for 4 hours and then stirred 18 hours at room temperature. The mixture was evaporated to a small volume, diluted with 100 parts water and extracted with ether. The ether extract was washed with saturated sodium bicarbonate, saturated sodium chloride solution and dried over magnesium sulfate. Evaporation of the ether gave 6 parts of crude ethyl 2-[(2-methylphenyl)acetyl]tetradecanoate as an oil which was not further purified.

Fuente