Reacción #543788

Ecuación de reacción

5-benzyloxy-2-hydroxymethyl-4-pyrone

Kojic acid

ammonia

Erol

→

5-Benzyloxy-2-hydroxymethyl-1H-pyridin-4-one

Disolventes

ethanol

Condiciones de reacción

Tratamiento posterior

1. 1
   Temperaturato reflux overnight
2. 2
   Filtraciónthen filtered
3. 3
   LavadoThe resultant solid was washed with ether
4. 4
   Otrodried in vacuo (5.9 g)

Procedimiento

A mixture of 5-benzyloxy-2-hydroxymethyl-4-pyrone (prepared from Kojic acid by the method of D. Erol, J. Med. Chem., 1994, 29, 893) (9.7 g, 40 mmol), concentrated aqueous (880) ammonia (100 ml), and ethanol (20 ml) was heated to reflux overnight. The mixture was allowed to cool to room temperature then filtered. The resultant solid was washed with ether and dried in vacuo (5.9 g).

Fuente