Reacción #543538

Ecuación de reacción

isoserine

methanol

HCl

HCl

→

product

Rendimiento 92.0%

Methyl 3-amino-2-hydroxypropionate hydrochloride

Rendimiento 92.0%

Condiciones de reacción

Tratamiento posterior

1. 1
   workup.DISSOLUTIONThe solid material slowly dissolved
2. 2
   Otroto yield a pale yellow liquid after a few minutes
3. 3
   OtroExcess HCl gas was removed
4. 4
   Otroby bubbling nitrogen into the reaction mixture
5. 5
   Otrothe solvent was removed under reduced pressure

Procedimiento

A suspension of isoserine (18) (20.0 g, 0.19 mol) in anhydrous methanol (100 mL) was saturated with HCl gas at 0° C. while being stirred with exclusion of moisture. The solid material slowly dissolved to yield a pale yellow liquid after a few minutes. The HCl saturated solution was stirred overnight (20 h) at room temperature. Excess HCl gas was removed by bubbling nitrogen into the reaction mixture and the solvent was removed under reduced pressure to yield the product as a syrup (27.1 g; yield 92%) Mass Spectrum M+H 120. The product was immediately taken to the next step without further purification.

Fuente