Reacción #5430

Ecuación de reacción

potassium hydroxide

4-ethoxycarbonyl-2-methylthiothiazole-5-carboxylic acid-tert-butylamide

→

5-tert-Butylaminocarbonyl-2-methylthiothiazole-4-carboxylic acid

Disolventes

water

water ethanol

Condiciones de reacción

Tratamiento posterior

1. 1
   Temperaturathe mixture was refluxed for 2 hours
2. 2
   OtroThe solvent mixture was then removed under reduced pressure
3. 3
   FiltraciónThe precipitated product was filtered off
4. 4
   Otrodried

Procedimiento

0.82 g (14.6 mmol) of potassium hydroxide in 10 ml of water was added to a solution of 4.00 g (13.2 mmol) of 4-ethoxycarbonyl-2-methylthiothiazole-5-carboxylic acid-tert-butylamide in 50 ml of water/ethanol (2:1), and the mixture was refluxed for 2 hours. The solvent mixture was then removed under reduced pressure and the residue was taken up in 50 ml of water and acidified with concentrated hydrochloric acid. The precipitated product was filtered off and dried.

Fuente