Reacción #5429

Ecuación de reacción

4-ethoxycarbonyl-2-methylthiothiazole-5-carboxylic acid chloride

tert-butylamine

hydrochloric acid

→

product

Rendimiento 100.2%

4-Ethoxycarbonyl-2-methylthiothiazole-5-carboxylic acid-tert-butylamide

Rendimiento 100.2%

Disolventes

dichloromethane

dichloromethane

Condiciones de reacción

Tratamiento posterior

1. 1
   Otrothe organic phase was separated
2. 2
   Lavadowashed with 50 ml of water
3. 3
   Secadodried over sodium sulfate
4. 4
   OtroThe solvent was removed under reduced pressure

Procedimiento

3.50 g (13.2 mmol) of 4-ethoxycarbonyl-2-methylthiothiazole-5-carboxylic acid chloride was dissolved in 20 ml of dichloromethane and dripped, at 0° C., into a solution of 3.20 g (44 mmol) of tert-butylamine in 50 ml of dichloromethane. The mixture was allowed to warm up to room temperature and was then stirred for 14 hours. 100 ml of 10% strength hydrochloric acid was added and the organic phase was separated, washed with 50 ml of water and dried over sodium sulfate. The solvent was removed under reduced pressure, leaving 4.00 g (100%) of product as a yellow crystalline slurry.

Fuente