Reacción #5423

Ecuación de reacción

N-(3-trifluoromethylphenyl)-N'-ethoxycarbonylthiourea

dibromoethane

potassium carbonate

→

2-ethoxycarbonylimino-3-(3-trifluoromethylphenyl)thiazolidine

Rendimiento 83.1%

Disolventes

acetone

Condiciones de reacción

Tratamiento posterior

1. 1
   OtroThe solvent was removed by distillation
2. 2
   Extracciónthe residue was extracted with diethyl ether
3. 3
   LavadoThe extract was washed with water
4. 4
   Secadodried over anhydrous magnesium sulfate
5. 5
   Concentraciónconcentrated under reduced pressure
6. 6
   OtroThe residue was recrystallized from a mixture of hexane and ethanol

Procedimiento

A solution of N-(3-trifluoromethylphenyl)-N'-ethoxycarbonylthiourea (1.8 g), dibromoethane (1.29 g) and anhydrous potassium carbonate (2.6 g) in acetone (20 ml) was refluxed for 5 hours. The solvent was removed by distillation, and the residue was extracted with diethyl ether. The extract was washed with water, dried over anhydrous magnesium sulfate and concentrated under reduced pressure. The residue was recrystallized from a mixture of hexane and ethanol to give 1.63 g of 2-ethoxycarbonylimino-3-(3-trifluoromethylphenyl)thiazolidine. m.p., 75.8° C.

Fuente