Reacción #54187

Ecuación de reacción

NaOH

6-methoxy-2-methyl-2H-pyran-3(6H)-one

chlorine

→

maltol

Disolventes

water

acetic acid

Condiciones de reacción

Tratamiento posterior

1. 1
   TemperaturaThe reaction mixture was then heated
2. 2
   Temperaturato reflux for about one hour
3. 3
   Extracciónthe reaction mixture extracted with chloroform
4. 4
   ExtracciónThe chloroform extract
5. 5
   Concentraciónwas concentrated

Procedimiento

A solution of 6-methoxy-2-methyl-2H-pyran-3(6H)-one (0.01 mole) in 20 ml of acetic acid was treated with gaseous chlorine (0.01 mole) at room temperature. The reaction mixture was then heated to reflux for about one hour, cooled to room temperature, diluted with 20 ml of water, the pH adjusted with 50% NaOH solution to 7.0 and the reaction mixture extracted with chloroform. The chloroform extract was concentrated to yield maltol which was recrystallized from methanol to give the pure product (56%), mp 159.5°-160.5° C.

Fuente