Reacción #5418

Ecuación de reacción

2-(acetylimino)-3-(3-trifluoromethylphenyl)-5-methylthiazoline

hydrochloric acid

→

2-imino-3-(3-trifluoromethylphenyl)-5-methylthiazoline

Rendimiento 46.5%

Disolventes

ethanol water

Condiciones de reacción

Tratamiento posterior

1. 1
   Temperaturawas refluxed for 3 hours
2. 2
   OtroEthanol was removed by distillation under reduced pressure
3. 3
   Extracciónextracted with ethyl acetate
4. 4
   Secadodried over anhydrous magnesium sulfate
5. 5
   OtroThe solvent was removed by distillation under reduced pressure

Procedimiento

A mixture of 2-(acetylimino)-3-(3-trifluoromethylphenyl)-5-methylthiazoline (1 g) and hydrochloric acid (38 %, 4 ml) in ethanol-water (1:2, 15 ml) was refluxed for 3 hours. Ethanol was removed by distillation under reduced pressure, and the residue was neutralized with potassium carbonate, extracted with ethyl acetate and dried over anhydrous magnesium sulfate. The solvent was removed by distillation under reduced pressure to give 0.4 g of 2-imino-3-(3-trifluoromethylphenyl)-5-methylthiazoline (Compound (xi)).

Fuente