Reacción #54151

Ecuación de reacción

2-hydroxy-4-methoxybenzaldehyde

ethyl acetoacetate

→

3-acetyl-7-methoxycoumarin

Condiciones de reacción

Tratamiento posterior

1. 1
   Temperaturawas warmed on a hot plate until solution
2. 2
   Temperaturato be heated gently
3. 3
   workup.WAITAfter several minutes the reaction mixture solidified
4. 4
   TemperaturaAfter cooling
5. 5
   Otrothe product was recrystallized from a mixture of alcohol and acetonitrile

Procedimiento

A mixture of 15.2 g 2-hydroxy-4-methoxybenzaldehyde and 13.5 g ethyl acetoacetate was warmed on a hot plate until solution was attained. Thirty drops of piperidine were added and the reaction mixture continued to be heated gently. After several minutes the reaction mixture solidified. After cooling, the product was recrystallized from a mixture of alcohol and acetonitrile. Yield 20 g.

Fuente