Reacción #54092

ord-02ef3f6c42b84d9caaf66c54b9f98454

Ecuación de reacción

CC1=CC(C)(C)Nc2ccc(OS(=O)(=O)C(F)(F)F)cc21
Trifluoromethanesulfonic acid 2,2,4-trimethyl-1,2-dihydroquinolin-6-yl ester
OB(O)c1ccccc1C(F)(F)F
2-trifluoromethylphenylboronic acid
SCCc1ccccc1
2-phenylethanethiol
→
CC1(C)C=C(CSCCc2ccccc2)c2cc(-c3ccccc3C(F)(F)F)ccc2N1
title compound
CC1(C)C=C(CSCCc2ccccc2)c2cc(-c3ccccc3C(F)(F)F)ccc2N1
2,2-Dimethyl-4-phenethylsulfanylmethyl-6-(2-trifluoromethylphenyl)-1,2-dihydroquinoline

Reactantes

CC1=CC(C)(C)Nc2ccc(OS(=O)(=O)C(F)(F)F)cc21
Trifluoromethanesulfonic acid 2,2,4-trimethyl-1,2-dihydroquinolin-6-yl ester
OB(O)c1ccccc1C(F)(F)F
2-trifluoromethylphenylboronic acid
SCCc1ccccc1
2-phenylethanethiol

Reactivos

Ninguno

Condiciones de reacción

Condiciones detalladas
See reaction.notes.procedure_details.

Procedimiento

Trifluoromethanesulfonic acid 2,2,4-trimethyl-1,2-dihydroquinolin-6-yl ester was coupled with 2-trifluoromethylphenylboronic acid. Bromination and coupling reaction with 2-phenylethanethiol gave 49 mg of the title compound.

Fuente

DOI: 10.6084/m9.figshare.5104873.v1Patente: US06858627B2uspto-grants-2005_02