Reacción #54089

ord-3be84da476fd47cf9556926b85e65745

Ecuación de reacción

CC1=CC(C)(C)Nc2ccc(OS(=O)(=O)C(F)(F)F)cc21
Trifluoromethanesulfonic acid 2,2,4-trimethyl-1,2-dihydroquinolin-6-yl ester
COc1ccc(F)cc1B(O)O
5-fluoro-2-methoxyphenylboronic acid
C=CCS
allyl mercaptan
→
C=CCSCC1=CC(C)(C)Nc2ccc(-c3cc(F)ccc3OC)cc21
title compound
C=CCSCC1=CC(C)(C)Nc2ccc(-c3cc(F)ccc3OC)cc21
4-Allylsulfanylmethyl-6-(5-fluoro-2-methoxyphenyl)-2,2-dimethyl-1,2-dihydroquinoline

Reactantes

CC1=CC(C)(C)Nc2ccc(OS(=O)(=O)C(F)(F)F)cc21
Trifluoromethanesulfonic acid 2,2,4-trimethyl-1,2-dihydroquinolin-6-yl ester
COc1ccc(F)cc1B(O)O
5-fluoro-2-methoxyphenylboronic acid
C=CCS
allyl mercaptan

Reactivos

Ninguno

Condiciones de reacción

Condiciones detalladas
See reaction.notes.procedure_details.

Procedimiento

(Trifluoromethanesulfonic acid 2,2,4-trimethyl-1,2-dihydroquinolin-6-yl ester was coupled with 5-fluoro-2-methoxyphenylboronic acid. Bromination and coupling reaction with allyl mercaptan gave 17 mg of the title compound.

Fuente

DOI: 10.6084/m9.figshare.5104873.v1Patente: US06858627B2uspto-grants-2005_02