Reacción #54088

ord-09f2e77fd9ff43c0aac52f79acada4a5

Ecuación de reacción

CC1=CC(C)(C)Nc2ccc(OS(=O)(=O)C(F)(F)F)cc21
Trifluoromethanesulfonic acid 2,2,4-trimethyl-1,2-dihydroquinolin-6-yl ester
COc1ccc(B(O)O)cc1OC
3,4-dimethoxyphenylboronic acid
SCCc1ccccc1
2-phenylethanethiol
→
COc1ccc(-c2ccc3c(c2)C(CSCCc2ccccc2)=CC(C)(C)N3)cc1OC
title compound
COc1ccc(-c2ccc3c(c2)C(CSCCc2ccccc2)=CC(C)(C)N3)cc1OC
6-(3,4-Dimethoxyphenyl)-2,2-dimethyl-4-phenethylsulfanylmethyl-1,2-dihydroquinoline

Reactantes

CC1=CC(C)(C)Nc2ccc(OS(=O)(=O)C(F)(F)F)cc21
Trifluoromethanesulfonic acid 2,2,4-trimethyl-1,2-dihydroquinolin-6-yl ester
COc1ccc(B(O)O)cc1OC
3,4-dimethoxyphenylboronic acid
SCCc1ccccc1
2-phenylethanethiol

Reactivos

Ninguno

Condiciones de reacción

Condiciones detalladas
See reaction.notes.procedure_details.

Procedimiento

Trifluoromethanesulfonic acid 2,2,4-trimethyl-1,2-dihydroquinolin-6-yl ester was coupled with 3,4-dimethoxyphenylboronic acid. Bromination and coupling reaction with 2-phenylethanethiol gave 10 mg the title compound.

Fuente

DOI: 10.6084/m9.figshare.5104873.v1Patente: US06858627B2uspto-grants-2005_02