Reacción #54081

ord-7038e07fd43c47049bcde43c3da206c3

Ecuación de reacción

CC1=CC(C)(C)Nc2ccc(OS(=O)(=O)C(F)(F)F)cc21
Trifluoromethanesulfonic acid 2,2,4-trimethyl-1,2-dihydroquinolin-6-yl ester
CSc1ccccc1B(O)O
2-(methylthio)phenylboronic acid
SCCc1ccccc1
2-phenylethanethiol
→
CSc1ccccc1-c1ccc2c(c1)C(CSCCc1ccccc1)=CC(C)(C)N2
title compound
CSc1ccccc1-c1ccc2c(c1)C(CSCCc1ccccc1)=CC(C)(C)N2
2,2-Dimethyl-6-(2-methylsulfanylphenyl)-4-phenethylsulfanylmethyl-1,2-dihydroquinoline

Reactantes

CC1=CC(C)(C)Nc2ccc(OS(=O)(=O)C(F)(F)F)cc21
Trifluoromethanesulfonic acid 2,2,4-trimethyl-1,2-dihydroquinolin-6-yl ester
CSc1ccccc1B(O)O
2-(methylthio)phenylboronic acid
SCCc1ccccc1
2-phenylethanethiol

Reactivos

Ninguno

Condiciones de reacción

Condiciones detalladas
See reaction.notes.procedure_details.

Procedimiento

Trifluoromethanesulfonic acid 2,2,4-trimethyl-1,2-dihydroquinolin-6-yl ester was coupled with 2-(methylthio)phenylboronic acid. Bromination and coupling reaction with 2-phenylethanethiol gave 59 mg of the title compound.

Fuente

DOI: 10.6084/m9.figshare.5104873.v1Patente: US06858627B2uspto-grants-2005_02