Reacción #54080

ord-c19277094bb64775bc862ab3379cb694

Ecuación de reacción

CC1=CC(C)(C)Nc2ccc(OS(=O)(=O)C(F)(F)F)cc21
Trifluoromethanesulfonic acid 2,2,4-trimethyl-1,2-dihydroquinolin-6-yl ester
OB(O)c1ccccc1-c1ccccc1
2-biphenylboronic acid
SCCc1ccccc1
2-phenylethanethiol
→
CC1(C)C=C(CSCCc2ccccc2)c2cc(-c3ccccc3-c3ccccc3)ccc2N1
title compound
CC1(C)C=C(CSCCc2ccccc2)c2cc(-c3ccccc3-c3ccccc3)ccc2N1
6-Biphenyl-2-yl-2,2-dimethyl-4-phenethylsulfanylmethyl-1,2-dihydroquinoline

Reactantes

CC1=CC(C)(C)Nc2ccc(OS(=O)(=O)C(F)(F)F)cc21
Trifluoromethanesulfonic acid 2,2,4-trimethyl-1,2-dihydroquinolin-6-yl ester
OB(O)c1ccccc1-c1ccccc1
2-biphenylboronic acid
SCCc1ccccc1
2-phenylethanethiol

Reactivos

Ninguno

Condiciones de reacción

Condiciones detalladas
See reaction.notes.procedure_details.

Procedimiento

Trifluoromethanesulfonic acid 2,2,4-trimethyl-1,2-dihydroquinolin-6-yl ester was coupled with 2-biphenylboronic acid. Bromination and coupling reaction with 2-phenylethanethiol gave 57 mg of the title compound.

Fuente

DOI: 10.6084/m9.figshare.5104873.v1Patente: US06858627B2uspto-grants-2005_02