Reacción #54077

ord-10d7b4f2a1324f74b8d42d98498ca57c

Ecuación de reacción

CC1=CC(C)(C)Nc2ccc(OS(=O)(=O)C(F)(F)F)cc21
Trifluoromethanesulfonic acid 2,2,4-trimethyl-1,2-dihydroquinolin-6-yl ester
Cc1ccccc1B(O)O
2-methylphenyl boronic acid
C=CCS
allyl mercaptan
→
C=CCSCC1=CC(C)(C)Nc2ccc(-c3ccccc3C)cc21
4-allylsulfanylmethyl-2,2-dimethyl-6-o-tolyl-1,2-dihydroquinoline

Reactantes

CC1=CC(C)(C)Nc2ccc(OS(=O)(=O)C(F)(F)F)cc21
Trifluoromethanesulfonic acid 2,2,4-trimethyl-1,2-dihydroquinolin-6-yl ester
Cc1ccccc1B(O)O
2-methylphenyl boronic acid
C=CCS
allyl mercaptan

Reactivos

Ninguno

Condiciones de reacción

Condiciones detalladas
See reaction.notes.procedure_details.

Procedimiento

Trifluoromethanesulfonic acid 2,2,4-trimethyl-1,2-dihydroquinolin-6-yl ester was coupled with 2-methylphenyl boronic acid. Bromination and coupling reaction with allyl mercaptan gave 35 mg of 4-allylsulfanylmethyl-2,2-dimethyl-6-o-tolyl-1,2-dihydroquinoline.

Fuente

DOI: 10.6084/m9.figshare.5104873.v1Patente: US06858627B2uspto-grants-2005_02