Reacción #54076

ord-f7f311fc6d8f4915bfb77b0b353c7d6e

Ecuación de reacción

CC1=CC(C)(C)Nc2ccc(OS(=O)(=O)C(F)(F)F)cc21
Trifluoromethanesulfonic acid 2,2,4-trimethyl-1,2-dihydroquinolin-6-yl ester
OB(O)c1ccccc1F
2-fluorophenyl boronic acid
SCCc1ccccc1
2-phenylethanethiol
→
CC1(C)C=C(CSCCc2ccccc2)c2cc(-c3ccccc3F)ccc2N1
title compound
CC1(C)C=C(CSCCc2ccccc2)c2cc(-c3ccccc3F)ccc2N1
6-(2-Fluorophenyl)-2,2-dimethyl-4-phenethylsulfanylmethyl-1,2-dihydroquinoline

Reactantes

CC1=CC(C)(C)Nc2ccc(OS(=O)(=O)C(F)(F)F)cc21
Trifluoromethanesulfonic acid 2,2,4-trimethyl-1,2-dihydroquinolin-6-yl ester
OB(O)c1ccccc1F
2-fluorophenyl boronic acid
SCCc1ccccc1
2-phenylethanethiol

Reactivos

Ninguno

Condiciones de reacción

Condiciones detalladas
See reaction.notes.procedure_details.

Procedimiento

Trifluoromethanesulfonic acid 2,2,4-trimethyl-1,2-dihydroquinolin-6-yl ester was coupled with 2-fluorophenyl boronic acid. Bromination and coupling reaction with 2-phenylethanethiol gave 72 mg of the title compound.

Fuente

DOI: 10.6084/m9.figshare.5104873.v1Patente: US06858627B2uspto-grants-2005_02