Reacción #54044

ord-4a5b08e9befb45b1b800a02c60dc6d92

Ecuación de reacción

COc1ccccc1-c1ccc2c(c1)C(CSC1CCCCC1)=CC(C)(C)N2
4-Cyclohexylsulfanylmethyl-6-(2-methoxyphenyl)-2,2-dimethyl-1,2-dihydroquinoline
COc1ccccc1-c1ccc2c(c1)C(CBr)=CC(C)(C)N2
4-bromomethyl-6-(2-methoxyphenyl)-2,2-dimethyl-1,2-dihydroquinoline
O=C([O-])[O-].[K+].[K+]
potassium carbonate
SC1CCCCC1
cyclohexylmercaptan
→
COc1ccccc1-c1ccc2c(c1)C(CNc1ccccc1)=CC(C)(C)N2
title compound
COc1ccccc1-c1ccc2c(c1)C(CNc1ccccc1)=CC(C)(C)N2
[6-(2-methoxyphenyl)-2,2-dimethyl-1,2-dihydroquinolin-4-ylmethyl]phenylamine

Reactantes

COc1ccccc1-c1ccc2c(c1)C(CSC1CCCCC1)=CC(C)(C)N2
4-Cyclohexylsulfanylmethyl-6-(2-methoxyphenyl)-2,2-dimethyl-1,2-dihydroquinoline
COc1ccccc1-c1ccc2c(c1)C(CBr)=CC(C)(C)N2
4-bromomethyl-6-(2-methoxyphenyl)-2,2-dimethyl-1,2-dihydroquinoline
O=C([O-])[O-].[K+].[K+]
potassium carbonate
SC1CCCCC1
cyclohexylmercaptan

Reactivos

Ninguno

Condiciones de reacción

Condiciones detalladas
See reaction.notes.procedure_details.

Procedimiento

4-Cyclohexylsulfanylmethyl-6-(2-methoxyphenyl)-2,2-dimethyl-1,2-dihydroquinoline 60 mg of 4-bromomethyl-6-(2-methoxyphenyl)-2,2-dimethyl-1,2-dihydroquinoline, 46 mg of potassium carbonate, and 27 μL of cyclohexylmercaptan reacted to give 5 mg of the title compound as an oil.

Fuente

DOI: 10.6084/m9.figshare.5104873.v1Patente: US06858627B2uspto-grants-2005_02