Reacción #53832

ord-b3d31884ab3b488b93786e6af807f0d5

Ecuación de reacción

CN[C@H]1CC[C@H](OCCCCBr)CC1.Cl
trans-[4-(4-Bromo-butoxy)-cyclohexyl]-methyl-amine hydrochloride
CC(C)COC(=O)Cl
isobutyl chloroformate
→
CC(C)COC(=O)N(C)[C@H]1CC[C@H](OCCCCBr)CC1
trans-[4-(4-Bromo-butoxy)-cyclohexyl]-methyl-carbamic acid isobutyl ester

Reactantes

CN[C@H]1CC[C@H](OCCCCBr)CC1.Cl
trans-[4-(4-Bromo-butoxy)-cyclohexyl]-methyl-amine hydrochloride
CC(C)COC(=O)Cl
isobutyl chloroformate

Reactivos

Ninguno

Condiciones de reacción

Condiciones detalladas
See reaction.notes.procedure_details.

Procedimiento

In analogy to example 11.4, trans-[4-(4-Bromo-butoxy)-cyclohexyl]-methyl-amine hydrochloride and isobutyl chloroformate (with 2.1 eq N,N-diisopropylethylamine) were reacted to yield trans-[4-(4-Bromo-butoxy)-cyclohexyl]-methyl-carbamic acid isobutyl ester which was used directly in the next steps see Example 12.45-12.54.

Fuente

DOI: 10.6084/m9.figshare.5104873.v1Patente: US06858651B2uspto-grants-2005_02