Reacción #53828

ord-f18248b807b24a6b93c9bf3b57112230

Ecuación de reacción

CN([C@H]1CC[C@H](O)CC1)S(=O)(=O)c1ccc(C(F)(F)F)cc1
trans-N-(4-Hydroxy-cyclohexyl)-N-methyl-4-trifluoromethyl-benzenesulfonamide
BrCCCBr
1,3-dibrompropane
→
CN([C@H]1CC[C@H](OCCCBr)CC1)S(=O)(=O)c1ccc(C(F)(F)F)cc1
trans-N-[4-(3-Bromo-propoxy)-cyclohexyl]-N-methyl-4-trifluoromethyl-benzenesulfonamide

Reactantes

CN([C@H]1CC[C@H](O)CC1)S(=O)(=O)c1ccc(C(F)(F)F)cc1
trans-N-(4-Hydroxy-cyclohexyl)-N-methyl-4-trifluoromethyl-benzenesulfonamide
BrCCCBr
1,3-dibrompropane

Reactivos

Ninguno

Condiciones de reacción

Condiciones detalladas
See reaction.notes.procedure_details.

Procedimiento

In analogy to example 11.11, trans-N-(4-Hydroxy-cyclohexyl)-N-methyl-4-trifluoromethyl-benzenesulfonamide and 1,3-dibrompropane were converted to yield trans-N-[4-(3-Bromo-propoxy)-cyclohexyl]-N-methyl-4-trifluoromethyl-benzenesulfonamide as off-white semisolid, MS: 320 [M−C3H6BrO].

Fuente

DOI: 10.6084/m9.figshare.5104873.v1Patente: US06858651B2uspto-grants-2005_02