Reacción #537914

Ecuación de reacción

N-(4-Amino-indan-2-ylmethyl)-propionamide

4-Isopropylbenzenesulfonyl chloride

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product

Rendimiento 101.4%

N-[4-(4-Isopropyl-benzenesulfonylamino)-indan-2-ylmethyl]-propionamide

Rendimiento 101.4%

Disolventes

pyridine dichloromethane

Condiciones de reacción

Tratamiento posterior

1. 1
   OtroSolution was evaporated
2. 2
   Otropartitioned between ethyl acetate and water
3. 3
   Otrothe organic phase separated
4. 4
   Secadodried over MgSO4
5. 5
   ConcentraciónThe filtered solution was concentrated

Procedimiento

N-(4-Amino-indan-2-ylmethyl)-propionamide (0.51 g, 2.34 mmol) was dissolved in pyridine-dichloromethane (1:2, 30 mL) and cooled to 5° C. 4-Isopropylbenzenesulfonyl chloride (0.54 g, 2.47 mmol) was added and the solution stirred at 5° C. for 3 h. Solution was evaporated, partitioned between ethyl acetate and water, and the organic phase separated and dried over MgSO4. The filtered solution was concentrated to give the product as a brown oil (0.95 g, 100%).

Fuente