Reacción #537912

Ecuación de reacción

N-(5-Amino-indan-2-ylmethyl)-propionamide

4-Isopropylbenzenesulfonyl chloride

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product

Rendimiento 99.0%

N-[5-(4-Isopropyl-benzenesulfonylamino)-indan-2-ylmethyl]-propionamide

Rendimiento 99.0%

Disolventes

pyridine dichloromethane

Condiciones de reacción

Tratamiento posterior

1. 1
   OtroSolution was evaporated
2. 2
   Otropartitioned between ethyl acetate and water
3. 3
   Otrothe organic phase separated
4. 4
   Secadodried over MgSO4
5. 5
   ConcentraciónThe filtered solution was concentrated

Procedimiento

N-(5-Amino-indan-2-ylmethyl)-propionamide (0.93 g, 4.26 mmol) was dissolved in pyridine-dichloromethane (1:2, 60 mL) and cooled to 5° C. 4-Isopropylbenzenesulfonyl chloride (0.98 g, 4.48 mmol) was added and the solution stirred at 5° C. for 3 h. Solution was evaporated, partitioned between ethyl acetate and water, and the organic phase separated and dried over MgSO4. The filtered solution was concentrated to give the product as a brown oil (1.69 g, 99%).

Fuente