Reacción #537566

Ecuación de reacción

2,3,6-trifluoro-5-nitropyridine

Intermediate 40

2,3,6-trifluoro-5-nitropyridine

5-methyl-1H-pyrazol-3-amine

DIPEA

→

5,6-Difluoro-N-(5-methyl-1H-pyrazol-3-yl)-3-nitropyridin-2-amine

Disolventes

EtOH

Condiciones de reacción

Tratamiento posterior

1. 1
   FiltraciónThe title compound was collected via filtration (780 mg)

Procedimiento

To a solution of 2,3,6-trifluoro-5-nitropyridine (Intermediate 40, 1.0 g) in EtOH (20 ml) at 0° C., was added 5-methyl-1H-pyrazol-3-amine (550 mg) and DIPEA (2 ml). The resulting mixture was stirred at this temperature overnight. The title compound was collected via filtration (780 mg). LCMS: 377 [M+1].

Fuente