Reacción #537020

Ecuación de reacción

(S)-isopropyl 7-cyano-1,2,3,4-tetrahydrocyclopenta[b]indol-2-ylcarbamate

4-chloro-2-(chloromethyl)-3-methoxypyridine

cesium carbonate

→

solid

Rendimiento 92.1%

(S)-4-((4-Chloro-3-methoxypyridin-2-yl)methyl)-7-cyano-1,2,3,4-tetrahydrocyclopenta[b]indol-2-ylcarbamic acid isopropyl ester

Rendimiento 92.1%

Disolventes

dimethylformamide

water

Condiciones de reacción

Tratamiento posterior

1. 1
   Filtraciónthe beige solid is filtered
2. 2
   LavadoIt is rinsed with water
3. 3
   Otrodried in a vacuum oven at 50° C. for 48 h

Procedimiento

To a solution of (S)-isopropyl 7-cyano-1,2,3,4-tetrahydrocyclopenta[b]indol-2-ylcarbamate (680 mg, 2.40 mmol) and 4-chloro-2-(chloromethyl)-3-methoxypyridine (553 mg, 2.88 mmol) in dimethylformamide (5 mL) is added cesium carbonate (1.17 g, 3.60 mmol) and the mixture stirred at room temperature overnight. The reaction mixture is diluted with water and the beige solid is filtered. It is rinsed with water and then dried in a vacuum oven at 50° C. for 48 h to obtain a gray solid (970 mg, 92%). LC-ES/MS m/z 439.0 [M+H]+.

Fuente