Reacción #535701

Ecuación de reacción

alpha cyclodextrin

alpha-lipoic acid

potassium hydroxide

potassium hydroxide

hydrochloric acid

→

Alpha-Lipoic Acid Alpha Cyclodextrin

Disolventes

water

Condiciones de reacción

Tratamiento posterior

1. 1
   workup.ADDITIONmixed at room temperature until clear
2. 2
   workup.ADDITIONmixed until clear (in case of the presence of amorphous silica
3. 3
   Otroprecipitating the complex
4. 4
   workup.STIRRINGThis mixture was stirred 55 minutes at room temperature
5. 5
   Otrodried immediately at about 180° C. inlet
6. 6
   Otroabout 80° C. outlet temperature

Procedimiento

29.95 kg of potassium hydroxide pellets (87.9%, 469.3 moles) were added to 1920.0 kg of water and mixed at room temperature until clear. The pH of this solution was at pH 14. 97.8 kg alpha-lipoic acid (98%, 464.5 moles) was added to the potassium hydroxide solution and mixed until clear (in case of the presence of amorphous silica as flowing agent the solution will be slightly cloudy). 555.1 kg alpha cyclodextrin (8.9% water content, 520.3 moles) was added and stirred 60 minutes at room temperature. 469.3 moles of 37.7% hydrochloric acid was added precipitating the complex. This mixture was stirred 55 minutes at room temperature. The final pH was at about pH 3. The final aqueous mixture was spray dried immediately at about 180° C. inlet and about 80° C. outlet temperature.

Fuente