Reacción #53550

Ecuación de reacción

nitric acid

2-bromo-m-xylene

→

2,6-dimethyl-3-nitrobromobenzene

Disolventes

acetic acid

Condiciones de reacción

Tratamiento posterior

1. 1
   Temperaturacooled in an ice bath (above freezing point)
2. 2
   Temperaturaheated at 80° C. for 2 hours or until the reaction
3. 3
   TemperaturaThe reaction mixture is cooled to room temperature
4. 4
   workup.STIRRINGwith stirring
5. 5
   OtroThe resulting yellow precipitates
6. 6
   Filtraciónare collected by suction filtration and air
7. 7
   Otrodried

Procedimiento

Fuming nitric acid (>90% yellow fuming HNO3) is slowly added to a solution of 2-bromo-m-xylene (20 g, 150 mmol) in acetic acid (100 ml) cooled in an ice bath (above freezing point). The resulting mixture is allowed to warm to room temperature, stirred for 1 hour, and heated at 80° C. for 2 hours or until the reaction is shown to be complete by GC/MS analysis following micro-scale base work-up. The reaction mixture is cooled to room temperature and poured into ice/water with stirring. The resulting yellow precipitates are collected by suction filtration and air dried to obtain 2,6-dimethyl-3-nitrobromobenzene.

Fuente