Reacción #53514

Ecuación de reacción

glycidyl tosylate

2-amino-3-nitrophenol

K2CO3

→

title compound

2-amino-3-nitro-1-(2,3-epoxypropoxy)benzene

Disolventes

acetone

Condiciones de reacción

Tratamiento posterior

1. 1
   Temperaturathe mixture is heated
2. 2
   Temperaturaat reflux for 18 hours
3. 3
   FiltraciónThe mixture is filtered
4. 4
   Otrothe solvent is evaporated under reduced pressure
5. 5
   OtroThe crude reaction product
6. 6
   Otrois purified by flash chromatography, elution

Procedimiento

21.7 g (0.095 mol) of glycidyl tosylate, 10 g (0.0475 mol) of 2-amino-3-nitrophenol and 6.5 g of crushed K2CO3 are mixed in acetone and the mixture is heated at reflux for 18 hours. The mixture is filtered and the solvent is evaporated under reduced pressure. The crude reaction product is purified by flash chromatography, elution being carried out with a 9/1 hexane/ethyl acetate mixture. The title compound is obtained. M.p.: 7°-78° C.

Fuente