Reacción #5337

Ecuación de reacción

syrup

Methyl 3-amino-2-[[2'-(ethoxycarbonyloxycarbamimidoyl)biphenyl-4-yl]methylamino]benzoate

tetraethoxymethane

acetic acid

→

title compound

Methyl 2-ethoxy-1-[[2'-(ethoxycarbonyloxy-carbamimidoyl)biphenyl-4-yl]methyl]benzimidazole-7-carboxylate

Disolventes

dioxane

Condiciones de reacción

Tratamiento posterior

1. 1
   ConcentraciónThe reaction mixture was concentrated to dryness
2. 2
   OtroThe residue was crystallized from ethyl acetate (50 ml)
3. 3
   OtroResulting crystalline precipitates
4. 4
   Filtraciónwere collected by filtration

Procedimiento

The pale brown syrup (8.58 g) obtained in Example (57a) was dissolved in dioxane (20 ml). To the solution were added tetraethoxymethane (8.64 g) and acetic acid (1.56 g). The mixture was stirred for 2 hours at 100° C. The reaction mixture was concentrated to dryness. The residue was crystallized from ethyl acetate (50 ml). Resulting crystalline precipitates were collected by filtration to obtain the title compound.

Fuente