Reacción #533697

Ecuación de reacción

compound

1-(2-{[6-({4-[{3-[({[(2S)-1′-{2-[(5R)-3-[3,5-Bis(trifluoromethyl)benzoyl]-5-(4-fluorophenyl)-1,3-oxazolidin-5-yl]ethyl}-2,3-dihydrospiro[indene-1,4′-piperidin]-2-yl]oxy}acetyl)(methyl)amino]propyl}(methyl)carbamoyl]-2-fluorophenyl}amino)hexanoyl](methyl)amino}ethyl)piperidin-4-yl biphenyl-2-ylcarbamate

hydrochloric acid dioxane

→

title compound

Rendimiento 80.0%

1-(2-{[6-({4-[{3-[({[(2S)-1′-{2-[(5R)-3-[3,5-Bis(trifluoromethyl)benzoyl]-5-(4-fluorophenyl)-1,3-oxazolidin-5-yl]ethyl}-2,3-dihydrospiro[indene-1,4′-piperidin]-2-yl]oxy}acetyl)(methyl)amino]propyl}(methyl)carbamoyl]-2-fluorophenyl}amino)hexanoyl](methyl)amino}ethyl)piperidin-4-yl biphenyl-2-ylcarbamate trihydrochloride

Rendimiento 80.0%

Disolventes

methanol

Condiciones de reacción

Tratamiento posterior

1. 1
   Otrothe solvent was evaporated under reduced pressure

Procedimiento

The compound (148 mg) obtained in Example 13d was dissolved in methanol (1 mL), 4 N hydrochloric acid-dioxane (0.108 mL, 0.434 mmol) was added, and the solvent was evaporated under reduced pressure to give the title compound (127 mg; yield, 80%) as a white solid.

Fuente