Reacción #53340

Ecuación de reacción

compound XVIII

(±)-8-Methyl-5-(4-nitrophenyl)-8,9-dihydro-7H-1,3-dioxolo[4,5-h][2,3]benzodiazepine-7-carbothiohydrazide

chloroform

methyl isocyanate

→

(±)-1-{8-Methyl-5-(4-nitrophenyl)-8,9-dihydro-7H-1,3-dioxolo[4,5-h][2,3]benzodiazepine-7-carbothioyl}-4-methyl-semicarbazide

Rendimiento 88.0%

Condiciones de reacción

Tratamiento posterior

1. 1
   LavadoAfter 1 h the reaction mixture was washed with sodium hydrogen carbonate solution and water
2. 2
   Concentraciónafter concentration the obtained solid material
3. 3
   Otrowas purified
4. 4
   Temperaturaby refluxing in ethanol

Procedimiento

To a stirred solution of 0.40 g (1.0 mmol) of compound XVIII in 15 ml of chloroform 0.07 ml (1.2 mmol) of methyl isocyanate was added. After 1 h the reaction mixture was washed with sodium hydrogen carbonate solution and water and after concentration the obtained solid material was purified by refluxing in ethanol. The desired product was 0.36 g, yield: 88%. Mp.: 200° C.

Fuente