Reacción #5333

Ecuación de reacción

methyl 3-iodobenzoate

toluene

→

title compound

Rendimiento 29.0%

Methyl 4'-methylbiphenyl-3-carboxylate

Rendimiento 29.0%

Disolventes

4-iodotoluene

Condiciones de reacción

Tratamiento posterior

1. 1
   FiltraciónInsoluble materials were filtered off
2. 2
   Concentraciónthe filtrate was concentrated to dryness
3. 3
   OtroThe residue was purified by column chromatography on silica gel

Procedimiento

To a mixture of methyl 3-iodobenzoate (26.1 g) in 4-iodotoluene (21.9 g) was added copper powder (31.8 g) gradually at 180°-190° C. The mixture was then stirred for 6 hours at 200°-210° C. The reaction mixture was cooled to room temperature, to which was added toluene. Insoluble materials were filtered off, and the filtrate was concentrated to dryness. The residue was purified by column chromatography on silica gel to afford the title compound as a colorless oil (6.61 g, 29%).

Fuente