Reacción #532941

Ecuación de reacción

8-bromo-1-(1,3-dimethyl-1H-pyrazol-4-yl)-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one

Intermediate A

8-bromo-1-(1,3-dimethyl-1H-pyrazol-4-yl)-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one

N-[2-chloro-5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-pyridin-3-yl]-methanesulfonamide

→

title compound

N-{2-Chloro-5-[1-(1,3-dimethyl-1H-pyrazol-4-yl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-c]quinolin-8-yl]-pyridin-3-yl}-methanesulfonamide

Condiciones de reacción

Tratamiento posterior

1. 1
   OtroThe title compound was synthesized in a similar manner

Procedimiento

The title compound was synthesized in a similar manner as described for Example 1.1 using 8-bromo-1-(1,3-dimethyl-1H-pyrazol-4-yl)-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one (Intermediate A) and N-[2-chloro-5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-pyridin-3-yl]-methanesulfonamide (Stage 223.1.1) to give the title compound as a white solid. (HPLC: tR 2.31 min (Method A); M+H=498 MS-ES; 1H-NMR (d6-DMSO, 400 MHz) 9.87 (s, 1H), 9.01 (s, 1H), 8.41-8.38 (m, 1H), 8.18-8.11 (m, 2H), 7.98-7.93 (m, 1H), 7.91-7.88 (m, 1H), 7.62-7.59 (m, 1H), 3.92 (s, 3H), 3.59 (s, 3H), 3.18 (s, 3H), 1.95 (s, 3H))

Fuente