Reacción #532885

Ecuación de reacción

8-bromo-1-(1-isopropyl-3-methyl-1H-pyrazol-4-yl)-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one

Intermediate G

8-bromo-1-(1-isopropyl-3-methyl-1H-pyrazol-4-yl)-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one

2-chloro-5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-pyridin-3-ylamine

→

title compound

8-(5-Amino-6-chloro-pyridin-3-yl)-1-(1-isopropyl-3-methyl-1H-pyrazol-4-yl)-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one

Condiciones de reacción

Tratamiento posterior

1. 1
   OtroThe title compound was synthesized in a similar manner

Procedimiento

The title compound was synthesized in a similar manner as described for Example 1.1 using 8-bromo-1-(1-isopropyl-3-methyl-1H-pyrazol-4-yl)-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one (Intermediate G, 0.098 mmol) and 2-chloro-5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-pyridin-3-ylamine (stage 152.1.1) to give the title compound as a yellow foam. (HPLC: tR 2.55 min (Method A); M+H=448 MS-ES; 1H-NMR (d6-DMSO, 400 MHz) 8.99 (s, 1H), 8.19 (s, 1H), 8.14-8.09 (m, 1H), 7.78-7.73 (m, 1H), 7.57-7.53 (m, 1H), 7.50-7.47 (m, 1H), 7.28-7.24 (m, 1H), 5.68 (s, br, 2H), 4.55 (hp, 1H), 3.58 (s, 3H), 1.95 (s, 3H), 1.44 (d, 6H))

Fuente