Reacción #53241

Ecuación de reacción

guanidine carbonate

ethyl acetoacetate

→

6-methyl-iso cytosine

Rendimiento 125.6%

Disolventes

ethanol

Condiciones de reacción

Tratamiento posterior

1. 1
   TemperaturaThe reaction solution was gradually heated
2. 2
   Temperaturato reflux temperature
3. 3
   OtroEthanol (300 mL) was evaporated
4. 4
   Temperaturathe reaction mixture was heated
5. 5
   Temperaturaunder reflux for two hours
6. 6
   TemperaturaAfter the reaction mixture was cooled
7. 7
   workup.ADDITION300 mL of hexane was added
8. 8
   FiltraciónThe resulting precipitate was filtered
9. 9
   Lavadowashed
10. 10
    Otrodried

Procedimiento

Dry ethanol (600 mL), 91.89 g of guanidine carbonate, and 146.1 g of ethyl acetoacetate were added to a 1 L flask. The reaction solution was gradually heated to reflux temperature and stirred overnight. Ethanol (300 mL) was evaporated, and the reaction mixture was heated under reflux for two hours. After the reaction mixture was cooled, 300 mL of hexane was added. The resulting precipitate was filtered, washed and dried. 119.3 g of 6-methyl-iso cytosine was obtained.

Fuente