Reacción #531790

Ecuación de reacción

Mercaptopropionic acid

Triphenylmethylchloride

→

3-(tritylthio)propanoic acid

Rendimiento 95.7%

3-(tritylthio) propanoic acid

Rendimiento 95.7%

Disolventes

methylene chloride

Condiciones de reacción

Tratamiento posterior

1. 1
   Otrowere carried out at room temperature
2. 2
   Filtraciónwas filtered
3. 3
   Lavadowas rinsed with 40 ml of diethyl ether
4. 4
   OtroThe precipitate was then dried under reduced pressure

Procedimiento

Mercaptopropionic acid 2 (3.14 g) was dissolved in 50 ml of methylene chloride. Triphenylmethylchloride 3 (8.36 g, 30 mmol) was added to that, and 19-hour protection reactions were carried out at room temperature. The precipitate generated through the protection reactions was filtered and gathered, and was rinsed with 40 ml of diethyl ether. The precipitate was then dried under reduced pressure, to form 9.86 g of 3-(tritylthio)propanoic acid 4, which is a white solid.

Fuente