Reacción #531402

Ecuación de reacción

1-(4-chlorobenzyl)piperazine

potassium carbonate

2-chloroethanol

→

title compound

Rendimiento 34.0%

1-(4-Chlorobenzyl)-4-(2-chloroethyl)piperazine

Rendimiento 34.0%

Disolventes

butanone

Condiciones de reacción

Tratamiento posterior

1. 1
   Temperaturaat reflux for 61/2 hr
2. 2
   Temperaturacooled
3. 3
   Otrothe solvent removed in vacuo

Procedimiento

A mixture of 1-(4-chlorobenzyl)piperazine (21.05 g; 0.1 mole), anhydrous potassium carbonate (20.7 g; 0.15 mole) and 2-chloroethanol (8.85 g; 0.11 mole) in butanone (270 ml) was stirred at reflux for 61/2 hr, cooled, and the solvent removed in vacuo. Chromatography of the residue on silica eluting with chloroform gave 8.74 g (34%) of the title compound as an oil, νmax (film) 3350, 2910, 2800, 1595 cm-1 ; (Found; C, 61.48; H, 7.96; N, 10.13; C13H19N2ClO requires; C, 61.28; H, 7.52; N, 11.00%).

Fuente