Reacción #531400

Ecuación de reacción

1-(4-chlorobenzyl)piperazine

8-allyl-4-benzyloxy-7-(2,3-epoxypropyloxy) coumarin

→

title compound

Rendimiento 52.5%

1-[3-(8-Allyl-4-benzyloxycoumarin-7-yloxy)-2-hydroxypropyl]-4-(4-chlorobenzyl)piperazine

Rendimiento 52.5%

Disolventes

ethanol

Condiciones de reacción

Tratamiento posterior

1. 1
   TemperaturaHeating
2. 2
   Temperaturato reflux for 2 hr

Procedimiento

Heating a mixture of 1-(4-chlorobenzyl)piperazine (6.2 g; 0.03 mole) and 8-allyl-4-benzyloxy-7-(2,3-epoxypropyloxy) coumarin (9.47 g; 0.026 mole) in ethanol (50 ml) to reflux for 2 hr and work-up as in Example 2(b) gave 7.85 g (52%) of the title compound of m.p. 155°-157° C., νmax (mull) 3320, 1675, 1615, 1605, 1565 cm-1 ; (Found; C, 69.04; H, 6.20; N, 4.67; Cl, 6.12; C33H35O5N2Cl requires; C, 68.92; H, 6.13; N, 4.87; Cl, 6.17%).

Fuente