Reacción #5310

Ecuación de reacción

Dihydropyran

4-chlorobutanol

→

title compound

Rendimiento 89.9%

2-[(4-Chlorobutyl)oxy]tetrahydropyran

Rendimiento 89.9%

Condiciones de reacción

Tratamiento posterior

1. 1
   Lavadowashed with H2O (100 ml), aqueous NaHCO3 (1 M, 50 ml) and BR (50 ml)
2. 2
   TemperaturaThe dried liquid was heated under reduced pressure

Procedimiento

Dihydropyran (15.5 g) was added dropwise to a mixture of 4-chlorobutanol (20 g) and hydrochloric acid (18 M, 1 drop) at RT. The mixture was stirred for 30 min and washed with H2O (100 ml), aqueous NaHCO3 (1 M, 50 ml) and BR (50 ml). The dried liquid was heated under reduced pressure to leave the title compound as a colourless liquid (31.9 g). T.l.c. [L] Rf 0.5.

Fuente