Reacción #52974

ord-e289917f90c34e19a672af8536fd0f3c

Ecuación de reacción

CCOC(=O)[C@H](Cc1ccc(-c2c(O)cccc2OC)cc1)NC(=O)c1c(Cl)cccc1Cl
N-(2,6-Dichlorobenzoyl)-4-(6-methoxy-2-hydroxyphenyl)-L-phenylalanine ethyl ester
[Li+].[OH-]
LiOH
→
COc1cccc(O)c1-c1ccc(C[C@H](NC(=O)c2c(Cl)cccc2Cl)C(=O)O)cc1
title compound
COc1cccc(O)c1-c1ccc(C[C@H](NC(=O)c2c(Cl)cccc2Cl)C(=O)O)cc1
N-(2,6-Dichlorobenzoyl)-4-(6-methoxy-2-hydroxyphenyl)-L-phenylalanine

Reactantes

CCOC(=O)[C@H](Cc1ccc(-c2c(O)cccc2OC)cc1)NC(=O)c1c(Cl)cccc1Cl
N-(2,6-Dichlorobenzoyl)-4-(6-methoxy-2-hydroxyphenyl)-L-phenylalanine ethyl ester
[Li+].[OH-]
LiOH

Reactivos

Ninguno

Condiciones de reacción

Condiciones detalladas
See reaction.notes.procedure_details.

Procedimiento

N-(2,6-Dichlorobenzoyl)-4-(6-methoxy-2-hydroxyphenyl)-L-phenylalanine ethyl ester was hydrolyzed with LiOH in a similar method as described in Example 1-5) to give the title compound. mp. 224.4° C., ESMS: m/z 460 (MH+), 458 (M−H)−.

Fuente

DOI: 10.6084/m9.figshare.5104873.v1Patente: US06855843B2uspto-grants-2005_02