Reacción #52679

Ecuación de reacción

3,3-dibromo-7-azaoxindole

acetic acid

→

7-aza-2-oxindole acetic acid salt

Rendimiento 91.0%

Disolventes

acetonitrile

Condiciones de reacción

Tratamiento posterior

1. 1
   OtroThe solids were removed by filtration
2. 2
   Otrothe solvent evaporated
3. 3
   workup.ADDITIONThe residue was treated with ethyl acetate
4. 4
   workup.ADDITIONThe ethyl acetate solution containing insoluble solid
5. 5
   OtroThe collected ethyl acetate solution was evaporated
6. 6
   Otrothe residue dried under vacuum

Procedimiento

Zinc dust (6.5 g) was added to a solution of 3,3-dibromo-7-azaoxindole (2.9 g) in acetic acid (20 ml) and acetonitrile (30 ml). The mixture was stirred for 2 hours at room temperature. The solids were removed by filtration and the solvent evaporated. The residue was treated with ethyl acetate. The ethyl acetate solution containing insoluble solid was passed through a short column of silica gel. The collected ethyl acetate solution was evaporated and the residue dried under vacuum to give 1.8 g (91% yield) of 7-aza-2-oxindole acetic acid salt.

Fuente